Xiap Metastasis

Tumor Suppressor Gene - Wikipedia, The Free Encyclopedia
A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer. When this gene mutates to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes. ... Read Article

Metastasis: An Overview - Ijomdas.com
Metastasis means the spread of the malignant cells from the origin site to a distant area. It involves the process of separation / detachment, (XIAP), in cancer cells can make them highly resistant to death stimuli, which has been shown to ... Return Document

XIAP Downregulation Promotes Caspase-dependent Inhibition Of ...
XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells Bing cell invasion in vitro and metastasis in vivo [13]. Clearly, in addi-tion to regulating apoptosis, XIAP participates in many processes ... Doc Viewer

Tuberous Sclerosis - Wikipedia, The Free Encyclopedia
Analysis has shown that the proliferative bronchiolar smooth muscle in tuberous sclerosis-related LAM is monoclonal metastasis from a coexisting renal angiomyolipoma. XIAP. XIAP2; See also intracellular signaling peptides and proteins. Authority control: GND: 4186390-2 ... Read Article

Mir-26 MicroRNA Precursor Family - Wikipedia, The Free ...
Mir-26 microRNA precursor family. mir-26 microRNA precursor family; Predicted secondary structure and induces apoptosis, and inhibits cell metastasis and invasion in vitro.Enhancer of zeste homolog 2 (EZH2) is a potential target of miR-26a. [19] ... Read Article

Down-Regulation Of Osteopontin Suppresses Growth And ...
Down-Regulation of Osteopontin Suppresses Growth and Metastasis of Hepatocellular Carcinoma Via Induction of Apoptosis Bcl-xL and XIAP expressions, increase of Bax expres-sion, and induction of a mitochondria-mediated apo-ptosis. ... View This Document

Interleukin-6 In Bone metastasis And Cancer Progression
Interleukin-6 in bone metastasis and cancer progression Tasnim Ara, Yves A. DeClerck * (XIAP), Bcl-2, Bcl-XL, tumor metastasis to the bone: challenges and opportunities. J Bone Miner Res 2003;18:190–4. 4. ... Return Document

Fucoidan Derived From Undaria Pinnatifida Induces Apoptosis ...
Fucoidan Derived from Undaria pinnatifida Induces Apoptosis in and inhibit metastasis and angiogenesis of Lewis lung XIAP and Livin and activation of caspase-3 and caspase-9. We suggest that the potent pro-apoptotic ... Fetch Doc

Differential Protein Expression In Small Intestinal ...
XIAP 9.75 0.00 P38 9.66 0.00 Stat 3 10.38 0.00 Alpha-tubulin 11.90 0.00 Cyclin E 0.15 6.67 (b) p-ERK 5.27 0.00 P27 9.61 0.00 Cdk2 0.56 0.00 Cdc25B 0.02 0 TISSUES: Tissue from liver metastasis, paired primary SIC compared to matched tissue ... Retrieve Here

Related Commentary, Page 3706 Research Article Targeting The ...
XIAP:p19/p12-CASP7 complex was constitutively present in nonapoptotic CASP3/DR cancer cells and inversely correlated correlated with cancer metastasis and recurrence and predicted poor overall and disease-free survival rates in clinical cohorts with diverse cancers ... Doc Retrieval

Curcumin (Diferuloylmethane) Downregulates Expression Of Cell ...
And metastasis through a mechanism not fully understood. Because several genes that mediate these processes are regulated by nuclear factor-κB (NF-κB), IAP2, XIAP, Bcl2, Bcl-xL, Bf1-1/A1, TRAF1, cFLIP) and metastasis (VEGF, MMP-9, ... Fetch This Document

Loss Of XIAP Sensitizes Colon Cancer Cells To PPAR ...
Loss of XIAP sensitizes colon cancer cells to PPARc independent antitumor effects of troglitazone and 15-PGJ2 Liang Qiaoa, Yun Daia,b, Qing Gua,b, metastasis in human gastrointestinal cancer cells, Int. J. Cancer 118 (2006) 571–576. ... Document Retrieval

Modulation Of Immune Signalling By Inhibitors Of Apoptosis - Cell
Modulation of immune signalling by inhibitors of apoptosis X-linked IAP (XIAP), the targets of which impact nuclear factor metastasis through NF-kB-induced alterations in cell motility signalling[3].TheE3ubiquitinligaseactivityofthe cIAPs ... Access This Document

Aspirin Suppresses The Growth And Metastasis Of Osteosarcoma ...
Inhibition of aspirin on migration, invasion, and metastasis of osteosarcoma is dependent on the NF-kB pathway. This is the first comprehensive evidence at the cellular levels and in the ... Access Doc

Upstate Cancer Research Institute: A Power House In Drug ...
Apoptosis: Bcl-2, Caspases, XIAP Angiogenesis: Eph-Ephrin Metastasis: Chemokine receptors Immune & Infectious Diseases Immune Response: CD4, CD8, IgSF HIV infection: Chemokine receptors SUNY Upstate Cancer Research Institute New York City Translating the Research Power of ... View This Document

Tetrathiomolybdate Inhibits Head And Neck Cancer metastasis ...
RESEARCH Open Access Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor ... Return Doc

Tu1893 Tumor Suppressor XAF1 And TRAIL Cooperate To Inhibit ...
Background: X-chromosome-linked IAP (XIAP) has been shown to be associated with tumor metastasis and TRAIL receptors function primarily as the metastasis suppressor. XIAP associ-ated factor 1 (XAF1), an antagonist of XIAP, can down-regulate expression of XIAP and up- ... Read Full Source

1534735413510557 - The Beljanski Foundation
DOI: 10.1177/1534735413510557 Integr Cancer Ther published online 27 November 2013 Hongqian Guo and Jun Yan Cunjie Chang, Wei Zhao, Bingxian Xie, Yongming Deng, XIAP; Figure 4B), and metastasis (VEGFa, MMP9, and GROα/CXCL1; Figure 4C-E). Though Pao ... Fetch Content

Distinctive Effects Of The Cellular Inhibitor Of Apoptosis ...
Invasion and metastasis. Consistent with the notion that IAPs play important roles in tumorigenesis, XIAp inhibition of c-IA p2 auto-degradation was dependent on this physical interaction, and it was independent of XIA p e3 ligase activity. ... Retrieve Content

AD AWARD NUMBER: W81XWH-04-1-0854 TITLE: Role Of The XIAP/AIF ...
AD_____ AWARD NUMBER: W81XWH-04-1-0854 TITLE: Role of the XIAP/AIF Axis in the Development and Progression of Prostate Cancer ... Return Doc

Bone Morphogenetic Protein-10 Suppresses The Growth And ...
From the Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, United Kingdom Purpose: BMPs have been implicated in the development of bone metastasis in XIAP (ILP) and ERK1/2 were activated. ... Fetch Document

Supplementary Table 1. Relationship Between P34SEI-1 And The ...
Supplementary Table 2. Relationship between XIAP and the clinical stage, grade, and size of breast tumors. Positive samples of XIAP Negative samples of XIAP Total ... Read Content

Molecular Pathways: Targeting Mdm2 And Mdm4 In Cancer Therapy
XIAP XIAP XIAP Mdm4 Mdm4 E2F1 Mdm4 Mdm2 Mdm2 Mdm2 Mdm2 Mdm2 Mdm2 Mdm2 Mdm2 Mdm2 Accumulation of XIAP E-cadherin degradation XIAP mRNA Target: gene Target: gene apoptosis, and metastasis. hnRNP, hnRNP K protein. B, Mdm4 interacts with p21 and E2F1 to regulate cell-cycle arrest and apoptosis. ... Read More